Systemic Scleroderma
|
|
0.090 |
GeneticVariation
|
BEFREE |
Among eight SSc-associated susceptibility polymorphisms which were applied for meta-analysis, IRF5 rs2004640 polymorphism (OR 1.12; 95% CI 1.02-1.22, P = 1.39 × 10<sup>-2</sup>), STAT4 rs7574865 polymorphism (OR 1.25; 95% CI 1.07-1.47, P = 5.3 × 10<sup>-3</sup>), IRAK1 rs1059702 polymorphism (OR 1.20; 95% CI 1.05-1.37, P = 0.007), and CTGF G-945C polymorphism (OR 1.42; 95% CI 1.18-1.71, P = 0.002) are associated with PF status in SSc, while TNFAIP3 rs5029939, CD226 rs763361, CD247 rs2056626, and IRF5 rs10488631 polymorphisms are not.
|
28434122 |
2017 |
Systemic Scleroderma
|
|
0.090 |
GeneticVariation
|
BEFREE |
The aim of this study was to investigate the association of signal transducer and activator of transcription 4 (STAT4) rs7574865 and interferon regulatory factor 5 (IRF5) rs2004640 polymorphisms with risk of SSc.
|
26712637 |
2016 |
Systemic Scleroderma
|
|
0.090 |
GeneticVariation
|
BEFREE |
The results demonstrated that STAT4 rs7574865 and IRF5 rs2004640G/T substitution are associated with a susceptibility to SSc, and they may serve as the SSc genetic susceptibility factor.
|
26712637 |
2016 |
Systemic Scleroderma
|
|
0.090 |
GeneticVariation
|
BEFREE |
However, the Chinese dcSSc did not show any association with the rs2004640.
|
25572744 |
2015 |
Systemic Scleroderma
|
|
0.090 |
GeneticVariation
|
BEFREE |
The SNP rs2004640 was significantly associated with SLE, MS, and SSc, but not with JIA [odds ratio (OR)=1.06, 95% confidence interval (CI)=0.90-1.24, P=0.48] or RA (OR=1.03, 95%CI=0.95-1.11, P=0.44).
|
25036352 |
2014 |
Systemic Scleroderma
|
|
0.090 |
GeneticVariation
|
BEFREE |
However, the association of rs2004640 with SSc was not independent of rs4728142 (conditioned P = 0.598).
|
23372721 |
2013 |
Systemic Scleroderma
|
|
0.090 |
GeneticVariation
|
BEFREE |
Identification of an association between IRF5 rs2004640 and systemic sclerosis (SSc) has highlighted a key role for type 1 interferon (IFN).
|
20231204 |
2010 |
Systemic Scleroderma
|
|
0.090 |
GeneticVariation
|
BEFREE |
An additive effect of the STAT4 rs7574865 T allele and the IRF5 rs2004640 T allele was observed, resulting in a multiple increased 1.28-fold risk of SSc.
|
19644887 |
2009 |
Systemic Scleroderma
|
|
0.090 |
GeneticVariation
|
BEFREE |
Conditional analysis revealed that rs2280714 could account for most of the association of these SNPs, while an additional contribution of rs2004640 was also suggested for dcSSc.
|
19479858 |
2009 |
Systemic Scleroderma
|
|
0.090 |
GeneticVariation
|
BEFREE |
The IRF5 rs2004640 GT substitution is associated with susceptibility to SSc.
|
19116937 |
2009 |